An important role for RUNX3 in human L1 transcription and retrotransposition

LINE-1s (long interspersed nuclear elements-1) are abundant non-LTR retrotransposons that comprise 17% of the human genome. The 5′ untranslated region (5′UTR) of human L1 (L1Hs) houses a poorly understood internal promoter. Here we report that mutations at a putative runt-domain transcription factor...

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Bibliographic Details
Main Authors: Yang, Nuo, Zhang, Lin, Zhang, Yue, Kazazian Jr, Haig H.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC169909/
https://ncbi.nlm.nih.gov/pubmed/12907736
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