Human L1 Retrotransposition: cis Preference versus trans Complementation

Long interspersed nuclear elements (LINEs or L1s) comprise approximately 17% of human DNA; however, only about 60 of the ∼400,000 L1s are mobile. Using a retrotransposition assay in cultured human cells, we demonstrate that L1-encoded proteins predominantly mobilize the RNA that encodes them. At muc...

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Main Authors: Wei, Wei, Gilbert, Nicolas, Ooi, Siew Loon, Lawler, Joseph F., Ostertag, Eric M., Kazazian, Haig H., Boeke, Jef D., Moran, John V.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
DNA Dynamics and Chromosome Structure
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC99594/
https://ncbi.nlm.nih.gov/pubmed/11158327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.4.1429-1439.2001
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