Human L1 Retrotransposition: cis Preference versus trans Complementation

Long interspersed nuclear elements (LINEs or L1s) comprise approximately 17% of human DNA; however, only about 60 of the ∼400,000 L1s are mobile. Using a retrotransposition assay in cultured human cells, we demonstrate that L1-encoded proteins predominantly mobilize the RNA that encodes them. At muc...

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Bibliographic Details

Published in:	Mol Cell Biol
Main Authors:	Wei, Wei, Gilbert, Nicolas, Ooi, Siew Loon, Lawler, Joseph F., Ostertag, Eric M., Kazazian, Haig H., Boeke, Jef D., Moran, John V.
Format:	Artigo
Language:	Inglês
Published:	Taylor & Francis 2001
Subjects:	DNA Dynamics and Chromosome Structure
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99594/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158327/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.4.1429-1439.2001
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