Rapid Growth of Invasive Metastatic Melanoma in Carcinogen-Treated Hepatocyte Growth Factor/Scatter Factor-Transgenic Mice Carrying an Oncogenic CDK4 Mutation

Currently, novel mouse models of melanoma are being generated that recapitulate the histopathology and molecular pathogenesis observed in human disease. Impaired cell-cycle control, which is a hallmark of both familial and sporadic melanoma, promotes slowly growing carcinogen-induced melanomas in th...

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Main Authors: Tormo, Damia, Ferrer, Aleix, Gaffal, Evelyn, Wenzel, Jörg, Basner-Tschakarjan, Etiena, Steitz, Julia, Heukamp, Lukas C., Gütgemann, Ines, Buettner, Reinhard, Malumbres, Marcos, Barbacid, Mariano, Merlino, Glenn, Tüting, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698803/
https://ncbi.nlm.nih.gov/pubmed/16877364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060017
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