Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants

The success of targeting kinases in cancer with small molecule inhibitors has been tempered by the emergence of drug-resistant kinase domain mutations. In patients with chronic myeloid leukemia treated with ABL inhibitors, BCR-ABL kinase domain mutations are the principal mechanism of relapse. Certa...

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Hlavní autoři: Skaggs, Brian J., Gorre, Mercedes E., Ryvkin, Ann, Burgess, Michael R., Xie, Yongming, Han, Yun, Komisopoulou, Evangelia, Brown, Lauren M., Loo, Joseph A., Landaw, Elliot M., Sawyers, Charles L., Graeber, Thomas G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698443/
https://ncbi.nlm.nih.gov/pubmed/17164333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609239103
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