Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants

The success of targeting kinases in cancer with small molecule inhibitors has been tempered by the emergence of drug-resistant kinase domain mutations. In patients with chronic myeloid leukemia treated with ABL inhibitors, BCR-ABL kinase domain mutations are the principal mechanism of relapse. Certa...

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Detalhes bibliográficos
Main Authors: Skaggs, Brian J., Gorre, Mercedes E., Ryvkin, Ann, Burgess, Michael R., Xie, Yongming, Han, Yun, Komisopoulou, Evangelia, Brown, Lauren M., Loo, Joseph A., Landaw, Elliot M., Sawyers, Charles L., Graeber, Thomas G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698443/
https://ncbi.nlm.nih.gov/pubmed/17164333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609239103
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