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Global Phosphoproteomics Reveals Crosstalk between Bcr-Abl and Negative Feedback Mechanisms Controlling Src Signaling
In subtypes and late stages of leukemias driven by the tyrosine kinase fusion protein Bcr-Abl, Src signaling critically contributes to the leukemic phenotype. We performed global tyrosine phosphoprofiling using quantitative mass spectrometry of Bcr-Abl transformed cells in which the activities of th...
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| Main Authors: | , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2011
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4057100/ https://ncbi.nlm.nih.gov/pubmed/21447799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001314 |
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