Contour Length and Refolding Rate of a Small Protein Controlled by Engineered Disulfide Bonds

The introduction of disulfide bonds into proteins creates additional mechanical barriers and limits the unfolded contour length (i.e., the maximal extension) measured by single-molecule force spectroscopy. Here, we engineer single disulfide bonds into four different locations of the human cardiac ti...

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Hauptverfasser: Ainavarapu, Sri Rama Koti, Brujić, Jasna, Huang, Hector H., Wiita, Arun P., Lu, Hui, Li, Lewyn, Walther, Kirstin A., Carrion-Vazquez, Mariano, Li, Hongbin, Fernandez, Julio M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Biophysical Society 2007
Schlagworte:
Proteins
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1697845/
https://ncbi.nlm.nih.gov/pubmed/17028145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.091561
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