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Ligand Binding Modulates the Mechanical Stability of Dihydrofolate Reductase
We use single-molecule force spectroscopy to demonstrate that the mechanical stability of the enzyme dihydrofolate reductase (DHFR) is modulated by ligand binding. In the absence of bound ligands, DHFR extends at very low forces, averaging 27 pN, without any characteristic mechanical fingerprint. By...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1366830/ https://ncbi.nlm.nih.gov/pubmed/16100277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.062034 |
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