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Influence of Substrate Binding on the Mechanical Stability of Mouse Dihydrofolate Reductase
We investigated the effect of substrate binding on the mechanical stability of mouse dihydrofolate reductase using single-molecule force spectroscopy by atomic force microscopy. We find that under mechanical forces dihydrofolate reductase unfolds via a metastable intermediate with lifetimes on the m...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Biophysical Society
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1366864/ https://ncbi.nlm.nih.gov/pubmed/16183885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.072066 |
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