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Preventing Disulfide Bond Formation Weakens Non-Covalent Forces among Lysozyme Aggregates

Nonnative disulfide bonds have been observed among protein aggregates in several diseases like amyotrophic lateral sclerosis, cataract and so on. The molecular mechanism by which formation of such bonds promotes protein aggregation is poorly understood. Here in this work we employ previously well ch...

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Detalhes bibliográficos
Main Authors: Ravi, Vijay Kumar, Goel, Mohit, Kotamarthi, Hema Chandra, Ainavarapu, Sri Rama Koti, Swaminathan, Rajaram
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925087/
https://ncbi.nlm.nih.gov/pubmed/24551048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087012
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