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General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2′-Modified Nucleotide Analogues

The hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B is an important target for antiviral therapies. NS5B is able to initiate viral RNA synthesis de novo and then switch to a fast and processive RNA elongation synthesis mode. The nucleotide analogue 2′-C-methyl CTP (2′-C-Me-CTP) is the acti...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Dutartre, Hélène, Bussetta, Cécile, Boretto, Joëlle, Canard, Bruno
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2006
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1693996/
https://ncbi.nlm.nih.gov/pubmed/17000745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00433-06
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