The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

Ethyl 2-methylimidazo[1,2-a]pyrrolo[2,3-c]pyridin-8-carboxylate (AG110) was identified as a potent inhibitor of pestivirus replication. The 50% effective concentration values for inhibition of bovine viral diarrhea virus (BVDV)-induced cytopathic effect, viral RNA synthesis, and production of infect...

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Main Authors: Paeshuyse, Jan, Chezal, Jean-Michel, Froeyen, Matheus, Leyssen, Pieter, Dutartre, Hélène, Vrancken, Robert, Canard, Bruno, Letellier, Carine, Li, Tong, Mittendorfer, Harald, Koenen, Frank, Kerkhofs, Pierre, De Clercq, Erik, Herdewijn, Piet, Puerstinger, Gerhard, Gueiffier, Alain, Chavignon, Olivier, Teulade, Jean-Claude, Neyts, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045526/
https://ncbi.nlm.nih.gov/pubmed/17686854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00388-07
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