A Novel, Highly Selective Inhibitor of Pestivirus Replication That Targets the Viral RNA-Dependent RNA Polymerase

We report on the highly potent and selective antipestivirus activity of 5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine (BPIP). The 50% effective concentration (EC(50)) for inhibition of bovine viral diarrhea virus (BVDV)-induced cytopathic effect formation was 0.04 ± 0.01 μM. Comparabl...

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Detalhes bibliográficos
Main Authors: Paeshuyse, Jan, Leyssen, Pieter, Mabery, Eric, Boddeker, Nina, Vrancken, Robert, Froeyen, Matheus, Ansari, Israrul H., Dutartre, Hélène, Rozenski, Jef, Gil, Laura H. V. G., Letellier, Carine, Lanford, Robert, Canard, Bruno, Koenen, Frank, Kerkhofs, Pierre, Donis, Ruben O., Herdewijn, Piet, Watson, Julia, De Clercq, Erik, Puerstinger, Gerhard, Neyts, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317535/
https://ncbi.nlm.nih.gov/pubmed/16352539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.1.149-160.2006
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