A Novel, Highly Selective Inhibitor of Pestivirus Replication That Targets the Viral RNA-Dependent RNA Polymerase

We report on the highly potent and selective antipestivirus activity of 5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine (BPIP). The 50% effective concentration (EC(50)) for inhibition of bovine viral diarrhea virus (BVDV)-induced cytopathic effect formation was 0.04 ± 0.01 μM. Comparabl...

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Main Authors: Paeshuyse, Jan, Leyssen, Pieter, Mabery, Eric, Boddeker, Nina, Vrancken, Robert, Froeyen, Matheus, Ansari, Israrul H., Dutartre, Hélène, Rozenski, Jef, Gil, Laura H. V. G., Letellier, Carine, Lanford, Robert, Canard, Bruno, Koenen, Frank, Kerkhofs, Pierre, Donis, Ruben O., Herdewijn, Piet, Watson, Julia, De Clercq, Erik, Puerstinger, Gerhard, Neyts, Johan
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2006
主題:
Vaccines and Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317535/
https://ncbi.nlm.nih.gov/pubmed/16352539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.1.149-160.2006
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