A Novel, Highly Selective Inhibitor of Pestivirus Replication That Targets the Viral RNA-Dependent RNA Polymerase

We report on the highly potent and selective antipestivirus activity of 5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine (BPIP). The 50% effective concentration (EC(50)) for inhibition of bovine viral diarrhea virus (BVDV)-induced cytopathic effect formation was 0.04 ± 0.01 μM. Comparabl...

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Κύριοι συγγραφείς: Paeshuyse, Jan, Leyssen, Pieter, Mabery, Eric, Boddeker, Nina, Vrancken, Robert, Froeyen, Matheus, Ansari, Israrul H., Dutartre, Hélène, Rozenski, Jef, Gil, Laura H. V. G., Letellier, Carine, Lanford, Robert, Canard, Bruno, Koenen, Frank, Kerkhofs, Pierre, Donis, Ruben O., Herdewijn, Piet, Watson, Julia, De Clercq, Erik, Puerstinger, Gerhard, Neyts, Johan
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2006
Θέματα:
Vaccines and Antiviral Agents
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317535/
https://ncbi.nlm.nih.gov/pubmed/16352539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.1.149-160.2006
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