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Structural basis for activation of α-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase
AIDS chemotherapy is limited by inadequate intracellular concentrations of the active triphosphate form of nucleoside analogues, leading to incomplete inhibition of viral replication and the appearance of drug-resistant virus. Drug activation by nucleoside diphosphate kinase and inhibition of HIV-1...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2000
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC313966/ https://ncbi.nlm.nih.gov/pubmed/10899107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.14.3520 |
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