The modeled structure of the RNA dependent RNA polymerase of GBV-C Virus suggests a role for motif E in Flaviviridae RNA polymerases

BACKGROUND: The Flaviviridae virus family includes major human and animal pathogens. The RNA dependent RNA polymerase (RdRp) plays a central role in the replication process, and thus is a validated target for antiviral drugs. Despite the increasing structural and enzymatic characterization of viral...

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Bibliographic Details
Main Authors: Ferron, François, Bussetta, Cécile, Dutartre, Hélène, Canard, Bruno
Format: Artigo
Language:Inglês
Published: BioMed Central 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283970/
https://ncbi.nlm.nih.gov/pubmed/16225688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-6-255
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