NF-κB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

NF-κB downregulates tumor necrosis factor (TNF)-induced c-Jun N-terminal kinase (JNK) activation that promotes cell death, but the mechanism is not yet fully understood. By using murine embryonic fibroblasts (MEFs) that are deficient in TNF receptor-associated factor (TRAF) 2 and TRAF5 (DKO) or p65...

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Hauptverfasser: Sakon, Sachiko, Xue, Xin, Takekawa, Mutsuhiro, Sasazuki, Tomonari, Okazaki, Tatsuma, Kojima, Yuko, Piao, Jian-Hu, Yagita, Hideo, Okumura, Ko, Doi, Takahiro, Nakano, Hiroyasu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2003
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC169052/
https://ncbi.nlm.nih.gov/pubmed/12881424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg379
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