Importin β1 Protein-mediated Nuclear Localization of Death Receptor 5 (DR5) Limits DR5/Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-induced Cell Death of Human Tumor Cells

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor 5 (DR5)-mediated cell death plays an important role in the elimination of tumor cells and transformed cells. Recently, recombinant TRAIL and agonistic anti-DR5 monoclonal antibodies have been developed and applied to canc...

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Main Authors: Kojima, Yuko, Nakayama, Masafumi, Nishina, Takashi, Nakano, Hiroyasu, Koyanagi, Makoto, Takeda, Kazuyoshi, Okumura, Ko, Yagita, Hideo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234854/
https://ncbi.nlm.nih.gov/pubmed/22020938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.309377
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