An antiapoptotic protein, c-FLIP(L), directly binds to MKK7 and inhibits the JNK pathway

Inhibition of NF-κB activation increases susceptibility to tumor necrosis factor (TNF)α-induced cell death, concurrent with caspases and prolonged c-Jun N-terminal kinase (JNK) activation, and reactive oxygen species (ROS) accumulation. However, the detailed mechanisms are unclear. Here we show that...

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Bibliografiske detaljer
Main Authors: Nakajima, Akihito, Komazawa-Sakon, Sachiko, Takekawa, Mutsuhiro, Sasazuki, Tomonari, Yeh, Wen-Chen, Yagita, Hideo, Okumura, Ko, Nakano, Hiroyasu
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1679768/
https://ncbi.nlm.nih.gov/pubmed/17110930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601423
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