Unique actinomycin D binding to self-complementary d(CXYGGCCY′X′G) sequences: duplex disruption and binding to a nominally base-paired hairpin

Actinomycin D (ACTD) has been shown to bind weakly to the sequence -GGCC-, despite the presence of a GpC site. It was subsequently found, however, that d(CATGGCCATG) binds relatively well to ACTD but exhibits unusually slow association kinetics, contrary to the strong-binding -XGCY- sites. In an eff...

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Vydáno v:	Nucleic Acids Res
Hlavní autoři:	Chen, Fu-Ming, Sha, Feng, Chin, Ko-Hsin, Chou, Shan-Ho
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 2003
Témata:	Articles
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC167638/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12853642/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg477
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