Unique actinomycin D binding to self-complementary d(CXYGGCCY′X′G) sequences: duplex disruption and binding to a nominally base-paired hairpin
Actinomycin D (ACTD) has been shown to bind weakly to the sequence -GGCC-, despite the presence of a GpC site. It was subsequently found, however, that d(CATGGCCATG) binds relatively well to ACTD but exhibits unusually slow association kinetics, contrary to the strong-binding -XGCY- sites. In an eff...
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| Yayımlandı: | Nucleic Acids Res |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2003
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC167638/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12853642/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg477 |
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