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Looped out and perpendicular: Deformation of Watson–Crick base pair associated with actinomycin D binding
Many anticancer drugs interact directly with DNA to exert their biological functions. To date, all noncovalent, intercalating drugs interact with DNA exclusively by inserting their chromophores into base steps to form elongated and unwound duplex structures without disrupting the flanking base pairs...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124453/ https://ncbi.nlm.nih.gov/pubmed/12011426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.102580399 |
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