Looped out and perpendicular: Deformation of Watson–Crick base pair associated with actinomycin D binding

Many anticancer drugs interact directly with DNA to exert their biological functions. To date, all noncovalent, intercalating drugs interact with DNA exclusively by inserting their chromophores into base steps to form elongated and unwound duplex structures without disrupting the flanking base pairs...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Chou, Shan-Ho, Chin, Ko-Hsin, Chen, Fu-Ming
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 2002
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124453/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12011426/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.102580399
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