Looped out and perpendicular: Deformation of Watson–Crick base pair associated with actinomycin D binding

Many anticancer drugs interact directly with DNA to exert their biological functions. To date, all noncovalent, intercalating drugs interact with DNA exclusively by inserting their chromophores into base steps to form elongated and unwound duplex structures without disrupting the flanking base pairs...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Chou, Shan-Ho, Chin, Ko-Hsin, Chen, Fu-Ming
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124453/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12011426/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.102580399
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