Looped out and perpendicular: Deformation of Watson–Crick base pair associated with actinomycin D binding

Many anticancer drugs interact directly with DNA to exert their biological functions. To date, all noncovalent, intercalating drugs interact with DNA exclusively by inserting their chromophores into base steps to form elongated and unwound duplex structures without disrupting the flanking base pairs...

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Εκδόθηκε σε:	Proc Natl Acad Sci U S A
Κύριοι συγγραφείς:	Chou, Shan-Ho, Chin, Ko-Hsin, Chen, Fu-Ming
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	National Academy of Sciences 2002
Θέματα:	Biological Sciences
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124453/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12011426/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.102580399
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