Looped out and perpendicular: Deformation of Watson–Crick base pair associated with actinomycin D binding

Many anticancer drugs interact directly with DNA to exert their biological functions. To date, all noncovalent, intercalating drugs interact with DNA exclusively by inserting their chromophores into base steps to form elongated and unwound duplex structures without disrupting the flanking base pairs...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Chou, Shan-Ho, Chin, Ko-Hsin, Chen, Fu-Ming
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 2002
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124453/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12011426/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.102580399
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!