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Unique actinomycin D binding to self-complementary d(CXYGGCCY′X′G) sequences: duplex disruption and binding to a nominally base-paired hairpin

Actinomycin D (ACTD) has been shown to bind weakly to the sequence -GGCC-, despite the presence of a GpC site. It was subsequently found, however, that d(CATGGCCATG) binds relatively well to ACTD but exhibits unusually slow association kinetics, contrary to the strong-binding -XGCY- sites. In an eff...

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Udgivet i:Nucleic Acids Res
Principais autores: Chen, Fu-Ming, Sha, Feng, Chin, Ko-Hsin, Chou, Shan-Ho
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC167638/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12853642/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg477
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