Induction of Robust Immune Responses against Human Immunodeficiency Virus Is Supported by the Inherent Tropism of Adeno-Associated Virus Type 5 for Dendritic Cells

The ability of adeno-associated virus serotype 1 to 8 (AAV1 to AAV8) vectors expressing the human immunodeficiency virus type 1 (HIV-1) Env gp160 (AAV-HIV) to induce an immune response was evaluated in BALB/c mice. The AAV5 vector showed a higher tropism for both mouse and human dendritic cells (DCs...

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Detalhes bibliográficos
Main Authors: Xin, Ke-Qin, Mizukami, Hiroaki, Urabe, Masashi, Toda, Yoshihiko, Shinoda, Kaori, Yoshida, Atsushi, Oomura, Kenji, Kojima, Yoshitsugu, Ichino, Motohide, Klinman, Dennis, Ozawa, Keiya, Okuda, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1676308/
https://ncbi.nlm.nih.gov/pubmed/17005662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00890-06
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