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Adeno-associated virus vector-mediated production of hepatocyte growth factor attenuates liver fibrosis in mice

PURPOSE: Adeno-associated virus (AAV) vectors can achieve long-term gene expression and are now feasible for use in human gene therapy. We constructed hepatocyte growth factor (HGF) expressing AAV (AAV5-HGF) and examined its effect in two mouse hepatic fibrosis models. METHODS: A model of hepatic fi...

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Detalhes bibliográficos
Main Authors: Suzumura, Kazuhiro, Hirano, Tadamichi, Son, Gakuhei, Iimuro, Yuji, Mizukami, Hiroaki, Ozawa, Keiya, Fujimoto, Jiro
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716862/
https://ncbi.nlm.nih.gov/pubmed/19669282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12072-007-9042-1
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