Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action

We have discovered a novel class of human immunodeficiency virus (HIV) reverse transcriptase (RT) inhibitors that block the polymerization reaction in a mode distinct from those of the nucleoside or nucleotide RT inhibitors (NRTIs) and nonnucleoside RT inhibitors (NNRTIs). For this class of indolopy...

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Detalhes bibliográficos
Main Authors: Jochmans, Dirk, Deval, Jérôme, Kesteleyn, Bart, Van Marck, Herwig, Bettens, Eva, De Baere, Inky, Dehertogh, Pascale, Ivens, Tania, Van Ginderen, Marcia, Van Schoubroeck, Bertrand, Ehteshami, Maryam, Wigerinck, Piet, Götte, Matthias, Hertogs, Kurt
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1676280/
https://ncbi.nlm.nih.gov/pubmed/17020946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00889-06
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