The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core Complex

Coronavirus entry is mediated by the viral spike (S) glycoprotein. The 180-kDa oligomeric S protein of the murine coronavirus mouse hepatitis virus strain A59 is posttranslationally cleaved into an S1 receptor binding unit and an S2 membrane fusion unit. The latter is thought to contain an internal...

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Bibliographic Details
Main Authors: Bosch, Berend Jan, van der Zee, Ruurd, de Haan, Cornelis A. M., Rottier, Peter J. M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC167208/
https://ncbi.nlm.nih.gov/pubmed/12885899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.16.8801-8811.2003
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