Retargeting of Coronavirus by Substitution of the Spike Glycoprotein Ectodomain: Crossing the Host Cell Species Barrier

Coronaviruses generally have a narrow host range, infecting one or just a few species. Using targeted RNA recombination, we constructed a mutant of the coronavirus mouse hepatitis virus (MHV) in which the ectodomain of the spike glycoprotein (S) was replaced with the highly divergent ectodomain of t...

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Bibliografski detalji

Izdano u:	J Virol
Glavni autori:	Kuo, Lili, Godeke, Gert-Jan, Raamsman, Martin J. B., Masters, Paul S., Rottier, Peter J. M.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2000
Teme:	Structure and Assembly
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111474/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10627550/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.3.1393-1406.2000
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