Cl(−) uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1

GABA is the principal inhibitory neurotransmitter in the mature brain, but during early postnatal development the elevated [Cl(−)](i) in immature neocortical neurones causes GABA(A) receptor activation to be depolarizing. The molecular mechanisms underlying this intracellular Cl(−) accumulation rema...

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Autors principals: Yamada, Junko, Okabe, Akihito, Toyoda, Hiroki, Kilb, Werner, Luhmann, Heiko J, Fukuda, Atsuo
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2004
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665166/
https://ncbi.nlm.nih.gov/pubmed/15090604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.062471
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