Cl(−) uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1

GABA is the principal inhibitory neurotransmitter in the mature brain, but during early postnatal development the elevated [Cl(−)](i) in immature neocortical neurones causes GABA(A) receptor activation to be depolarizing. The molecular mechanisms underlying this intracellular Cl(−) accumulation rema...

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Hlavní autoři: Yamada, Junko, Okabe, Akihito, Toyoda, Hiroki, Kilb, Werner, Luhmann, Heiko J, Fukuda, Atsuo
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2004
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665166/
https://ncbi.nlm.nih.gov/pubmed/15090604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.062471
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