Coincident glutamatergic depolarizations enhance GABA(A) receptor-dependent Cl(-) influx in mature and suppress Cl(-) efflux in immature neurons

The impact of GABAergic transmission on neuronal excitability depends on the Cl(-)-gradient across membranes. However, the Cl(-)-fluxes through GABA(A) receptors alter the intracellular Cl(-) concentration ([Cl(-)](i)) and in turn attenuate GABAergic responses, a process termed ionic plasticity. Rec...

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Udgivet i:PLoS Comput Biol
Main Authors: Lombardi, Aniello, Jedlicka, Peter, Luhmann, Heiko J., Kilb, Werner
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845986/
https://ncbi.nlm.nih.gov/pubmed/33465082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008573
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