Coincident glutamatergic depolarizations enhance GABA(A) receptor-dependent Cl(-) influx in mature and suppress Cl(-) efflux in immature neurons

The impact of GABAergic transmission on neuronal excitability depends on the Cl(-)-gradient across membranes. However, the Cl(-)-fluxes through GABA(A) receptors alter the intracellular Cl(-) concentration ([Cl(-)](i)) and in turn attenuate GABAergic responses, a process termed ionic plasticity. Rec...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Lombardi, Aniello, Jedlicka, Peter, Luhmann, Heiko J., Kilb, Werner
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845986/
https://ncbi.nlm.nih.gov/pubmed/33465082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008573
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