Cl(−) uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1

GABA is the principal inhibitory neurotransmitter in the mature brain, but during early postnatal development the elevated [Cl(−)](i) in immature neocortical neurones causes GABA(A) receptor activation to be depolarizing. The molecular mechanisms underlying this intracellular Cl(−) accumulation rema...

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Bibliographic Details
Main Authors: Yamada, Junko, Okabe, Akihito, Toyoda, Hiroki, Kilb, Werner, Luhmann, Heiko J, Fukuda, Atsuo
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2004
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665166/
https://ncbi.nlm.nih.gov/pubmed/15090604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.062471
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