Cl(−) uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1

GABA is the principal inhibitory neurotransmitter in the mature brain, but during early postnatal development the elevated [Cl(−)](i) in immature neocortical neurones causes GABA(A) receptor activation to be depolarizing. The molecular mechanisms underlying this intracellular Cl(−) accumulation rema...

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Main Authors: Yamada, Junko, Okabe, Akihito, Toyoda, Hiroki, Kilb, Werner, Luhmann, Heiko J, Fukuda, Atsuo
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2004
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665166/
https://ncbi.nlm.nih.gov/pubmed/15090604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.062471
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