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Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctions

Connexin40 (Cx40) contains a specific binding site for spermine (affinity ∼100 μm) whereas connexin43 (Cx43) is unaffected by identical concentrations of intracellular spermine. Replacement of two unique glutamate residues, E9 and E13, from the cytoplasmic amino terminal domain of Cx40 with the corr...

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Détails bibliographiques
Auteurs principaux: Musa, Hassan, Fenn, Edward, Crye, Mark, Gemel, Joanna, Beyer, Eric C, Veenstra, Richard D
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2004
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665163/
https://ncbi.nlm.nih.gov/pubmed/15107469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.059386
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