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Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctions
Connexin40 (Cx40) contains a specific binding site for spermine (affinity ∼100 μm) whereas connexin43 (Cx43) is unaffected by identical concentrations of intracellular spermine. Replacement of two unique glutamate residues, E9 and E13, from the cytoplasmic amino terminal domain of Cx40 with the corr...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Blackwell Science Inc
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1665163/ https://ncbi.nlm.nih.gov/pubmed/15107469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.059386 |
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