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Effect of Transjunctional KCl Gradients on the Spermine Inhibition of Connexin40 Gap Junctions
Spermine inhibits rat connexin40 (Cx40) gap junctions. Glutamate residues at positions 9 and 13 and a basic amino acid (HKH) motif at positions 15–17 on the amino terminal domain are essential for this inhibitory activity. Questions remain as to whether spermine occludes the channel within the ion p...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Biophysical Society
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1896261/ https://ncbi.nlm.nih.gov/pubmed/17468172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.098517 |
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