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Effect of Transjunctional KCl Gradients on the Spermine Inhibition of Connexin40 Gap Junctions

Spermine inhibits rat connexin40 (Cx40) gap junctions. Glutamate residues at positions 9 and 13 and a basic amino acid (HKH) motif at positions 15–17 on the amino terminal domain are essential for this inhibitory activity. Questions remain as to whether spermine occludes the channel within the ion p...

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Bibliografiske detaljer
Main Authors: Lin, Xianming, Veenstra, Richard D.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1896261/
https://ncbi.nlm.nih.gov/pubmed/17468172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.098517
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