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Effect of Transjunctional KCl Gradients on the Spermine Inhibition of Connexin40 Gap Junctions

Spermine inhibits rat connexin40 (Cx40) gap junctions. Glutamate residues at positions 9 and 13 and a basic amino acid (HKH) motif at positions 15–17 on the amino terminal domain are essential for this inhibitory activity. Questions remain as to whether spermine occludes the channel within the ion p...

詳細記述

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書誌詳細
主要な著者: Lin, Xianming, Veenstra, Richard D.
フォーマット: Artigo
言語:Inglês
出版事項: The Biophysical Society 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1896261/
https://ncbi.nlm.nih.gov/pubmed/17468172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.098517
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