Effect of Transjunctional KCl Gradients on the Spermine Inhibition of Connexin40 Gap Junctions

Spermine inhibits rat connexin40 (Cx40) gap junctions. Glutamate residues at positions 9 and 13 and a basic amino acid (HKH) motif at positions 15–17 on the amino terminal domain are essential for this inhibitory activity. Questions remain as to whether spermine occludes the channel within the ion p...

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Bibliographic Details
Main Authors: Lin, Xianming, Veenstra, Richard D.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2007
Subjects:
Channels, Receptors, and Electrical Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1896261/
https://ncbi.nlm.nih.gov/pubmed/17468172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.098517
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