GABA(B) receptor activation inhibits exocytosis in rat pancreatic β-cells by G-protein-dependent activation of calcineurin

We have investigated the regulation of hormone secretion from rat pancreatic islets by the GABA(B) receptors (GABA(B)Rs). Inclusion of the specific GABA(B)R antagonist CGP 55845 in the extracellular medium increased glucose-stimulated insulin secretion 1.6-fold but did not affect the release of gluc...

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Detalhes bibliográficos
Main Authors: Braun, Matthias, Wendt, Anna, Buschard, Karsten, Salehi, Albert, Sewing, Sabine, Gromada, Jesper, Rorsman, Patrik
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1665126/
https://ncbi.nlm.nih.gov/pubmed/15235087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.066563
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