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βL–βM loop in the C-terminal domain of G protein-activated inwardly rectifying K(+) channels is important for G(βγ) subunit activation
The activity of G protein-activated inwardly rectifying K(+) channels (GIRK or Kir3) is important for regulating membrane excitability in neuronal, cardiac and endocrine cells. Although G(βγ) subunits are known to bind the N- and C-termini of GIRK channels, the mechanism underlying G(βγ) activation...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Blackwell Science Inc
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1664862/ https://ncbi.nlm.nih.gov/pubmed/14724209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.056101 |
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