βL–βM loop in the C-terminal domain of G protein-activated inwardly rectifying K(+) channels is important for G(βγ) subunit activation

The activity of G protein-activated inwardly rectifying K(+) channels (GIRK or Kir3) is important for regulating membrane excitability in neuronal, cardiac and endocrine cells. Although G(βγ) subunits are known to bind the N- and C-termini of GIRK channels, the mechanism underlying G(βγ) activation...

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Bibliographic Details
Main Authors: Finley, Melissa, Arrabit, Christine, Fowler, Catherine, Suen, Ka Fai, Slesinger, Paul A
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2004
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1664862/
https://ncbi.nlm.nih.gov/pubmed/14724209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.056101
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