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Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K(+) channels
Local anesthetics, commonly used for treating cardiac arrhythmias, pain, and seizures, are best known for their inhibitory effects on voltage-gated Na(+) channels. Cardiovascular and central nervous system toxicity are unwanted side-effects from local anesthetics that cannot be attributed to the inh...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The National Academy of Sciences
2001
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC33494/ https://ncbi.nlm.nih.gov/pubmed/11353868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111447798 |
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