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RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K(+) channels

G protein-gated inward rectifier K(+) (GIRK) channels mediate hyperpolarizing postsynaptic potentials in the nervous system and in the heart during activation of Gα(i/o)-coupled receptors. In neurons and cardiac atrial cells the time course for receptor-mediated GIRK current deactivation is 20–40 ti...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Doupnik, Craig A., Davidson, Norman, Lester, Henry A., Kofuji, Paulo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23385/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9294233/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.19.10461
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