Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-β structure

Abnormal filaments consisting of hyperphosphorylated microtubule-associated protein tau form in the brains of patients with Alzheimer's disease, Down's syndrome, and various dementing tauopathies. In Alzheimer's disease and Down's syndrome, the filaments have two characteristic m...

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Sonraí Bibleagrafaíochta
Main Authors: Berriman, John, Serpell, Louise C., Oberg, Keith A., Fink, Anthony L., Goedert, Michel, Crowther, R. Anthony
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2003
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC166433/
https://ncbi.nlm.nih.gov/pubmed/12853572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1530287100
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