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Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation

Filamentous inclusions made of α-synuclein constitute the defining neuropathological characteristic of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Rare familial cases of Parkinson's disease are associated with mutations A53T and A30P in α-synuclein. We repo...

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Detalhes bibliográficos
Main Authors: Serpell, Louise C., Berriman, John, Jakes, Ross, Goedert, Michel, Crowther, R. Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18329/
https://ncbi.nlm.nih.gov/pubmed/10781096
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