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Human β-Synuclein Rendered Fibrillogenic by Designed Mutations

Filamentous inclusions made of α-synuclein are found in nerve cells and glial cells in a number of human neurodegenerative diseases, including Parkinson disease, dementia with Lewy bodies, and multiple system atrophy. The assembly and spreading of these inclusions are likely to play an important rol...

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Détails bibliographiques
Auteurs principaux: Zibaee, Shahin, Fraser, Graham, Jakes, Ross, Owen, David, Serpell, Louise C., Crowther, R. Anthony, Goedert, Michel
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992288/
https://ncbi.nlm.nih.gov/pubmed/20833719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.160721
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