Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

The deposition of protein aggregates in neurons is a hallmark of neurodegenerative diseases caused by polyglutamine (polyQ) proteins. We analyzed the effects of the heat shock protein (Hsp) 70 chaperone system on the aggregation of fragments of huntingtin (htt) with expanded polyQ tracts. In vitro,...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Muchowski, Paul J., Schaffar, Gregor, Sittler, Annie, Wanker, Erich E., Hayer-Hartl, Manajit K., Hartl, F. Ulrich
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2000
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16632/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10859365/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.140202897
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